Reversing aging by cell rejuvenation
Cell aging is the largest driver of modern diseases
Aging mechanisms are common to the major modern diseases, and the source of aging is each and every somatic cell. 51³Ô¹ÏÍø¹ÙÍø has built proprietary datasets that uncover the hidden biology of cell aging and rejuvenation, revealing a pipeline of druggable and disease relevant cell rejuvenation targets.



Aging is reversed between generations
Each of us developed from a single cell passed down by our parents, yet we’re not born at our parent’s age and we begin our post-development lives in full health. The biology inherited from our parents is safely scrubbed, renewed and restarted, with evidence of a in the embryo shortly after conception.

51³Ô¹ÏÍø¹ÙÍø finds a single gene that rejuvenates multiple cell types with greater safety
Yamanaka factors (OSKM) rejuvenate multiple cell types and extend the lifespan of mouse models, but were optimised to activate a tumor-inducing pathway, posing safety concerns for therapeutic development.
51³Ô¹ÏÍø¹ÙÍø's dataset enabled cell aging clock (AC3) and virtual cell have overcome this challenge, identifying genes that are individually sufficient to rejuvenate epigenetic age across multiple cell types (left or above) whilst decoupling the tumour inducing pluripotency pathway (below).
51³Ô¹ÏÍø¹ÙÍø is progressing a pipeline of cell rejuvenation assets
51³Ô¹ÏÍø¹ÙÍø's cell aging clock (AC3) and virtual cell reduce centuries of experiments to years, identifying 190 genes that individually affect the aging of real cells in vitro. 51³Ô¹ÏÍø¹ÙÍø is progressing proof of concept studies for SB000 expression in age-driven hearing loss and SB101 siRNA inhibition in fibrosis of the liver and heart.
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Leaders in virtual cells and cell aging clocks
51³Ô¹ÏÍø¹ÙÍø has assembled a world-class team of scientists that bridge machine learning and cell biology.

Senior advisor, Prof University of Toronto, Inventor of the virtual cell scGPT1

CSO and founder, PhD University of Cambridge, Inventor of the first accurate cell aging clock
Brendan received his PhD in Pharmacology from the University of Cambridge, where his focus was on basic research. First as an intern and then as a founder, Brendan began to prototype single-cell transcriptomic aging clocks, helping forge a new direction for 51³Ô¹ÏÍø¹ÙÍø. Since 2021, Brendan has led 51³Ô¹ÏÍø¹Ù꿉۪s science team in the search for new rejuvenating interventions, with the belief that these discoveries could have a massive impact across healthcare.

Head of ML, MPhil University of Cambridge, Inventor of the most accurate aging clock2
Leadership team
Current Investors
LATEST NEWS

51³Ô¹ÏÍø¹ÙÍø proposes improved ranking system for virtual cell models to accelerate gene target discovery

51³Ô¹ÏÍø¹ÙÍø identifies novel single-gene target for safer cellular rejuvenation therapeutics

51³Ô¹ÏÍø¹ÙÍø appoints Lord David Prior and Sir Tony Kouzarides to support long-term strategy for cell rejuvenation therapeutics
Careers
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